Dual-sgRNA CRISPR/Cas9 knockout of PD-L1 in human U87 glioblastoma tumor cells inhibits proliferation, invasion, and tumor-associated macrophage polarization

Programmed death ligand 1 (PD-L1) plays a key role in glioblastoma multiforme (GBM) immunosuppression, vitality, proliferation, and migration, and is therefore a promising target for treating GBM. CRISPR/Cas9-mediated genomic editing can delete both cell surface and intracellular PD-L1. This systemi...

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Detalles Bibliográficos
Autores principales: Fierro, Javier, DiPasquale, Jake, Perez, Joshua, Chin, Brandon, Chokpapone, Yathip, Tran, An M., Holden, Arabella, Factoriza, Chris, Sivagnanakumar, Nikhi, Aguilar, Rocio, Mazal, Sarah, Lopez, Melissa, Dou, Huanyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844083/
https://www.ncbi.nlm.nih.gov/pubmed/35165339
http://dx.doi.org/10.1038/s41598-022-06430-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844083/
https://www.ncbi.nlm.nih.gov/pubmed/35165339
http://dx.doi.org/10.1038/s41598-022-06430-1

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