Receptor for advanced glycation end products aggravates cognitive deficits in type 2 diabetes through binding of C‐terminal AAs 2‐5 to mitogen‐activated protein kinase kinase 3 (MKK3) and facilitation of MEKK3‐MKK3‐p38 module assembly

In this study, we explored the precise mechanisms underlying the receptor for advanced glycation end products (RAGE)‐mediated neuronal loss and behavioral dysfunction induced by hyperglycemia. We used immunoprecipitation (IP) and GST pull‐down assays to assess the interaction between RAGE and mitoge...

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Detalles Bibliográficos
Autores principales: Zhou, Xiao‐Yan, Ying, Chang‐Jiang, Hu, Bin, Zhang, Yu‐Sheng, Gan, Tian, Zhu, Yan‐Dong, Wang, Nan, Li, An‐An, Song, Yuan‐Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844116/
https://www.ncbi.nlm.nih.gov/pubmed/35080104
http://dx.doi.org/10.1111/acel.13543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844116/
https://www.ncbi.nlm.nih.gov/pubmed/35080104
http://dx.doi.org/10.1111/acel.13543

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