Cargando…

Proper control of R‐loop homeostasis is required for maintenance of gene expression and neuronal function during aging

Age‐related loss of cellular function and increased cell death are characteristic hallmarks of aging. While defects in gene expression and RNA metabolism have been linked with age‐associated human neuropathies, it is not clear how the changes that occur in aging neurons contribute to loss of gene ex...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jauregui‐Lozano, Juan, Escobedo, Spencer, Easton, Alyssa, Lanman, Nadia A., Weake, Vikki M., Hall, Hana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844117/ https://www.ncbi.nlm.nih.gov/pubmed/35048512 http://dx.doi.org/10.1111/acel.13554

Ejemplares similares

Proper splicing contributes to visual function in the aging Drosophila eye
por: Stegeman, Rachel, et al.
Publicado: (2018)

TRiP stocks contain a previously uncharacterized loss-of-function sevenless allele
por: Escobedo, Spencer E, et al.
Publicado: (2019)

The Clock:Cycle complex is a major transcriptional regulator of Drosophila photoreceptors that protects the eye from retinal degeneration and oxidative stress
por: Jauregui-Lozano, Juan, et al.
Publicado: (2022)

Aging and Light Stress Result in Overlapping and Unique Gene Expression Changes in Photoreceptors
por: Escobedo, Spencer E., et al.
Publicado: (2022)

R-loops in neuronal aging
por: Hall, Hana
Publicado: (2023)

Transcriptome profiling of aging Drosophila photoreceptors reveals gene expression trends that correlate with visual senescence
por: Hall, Hana, et al.
Publicado: (2017)

Establishing the contribution of active histone methylation marks to the aging transcriptional landscape of Drosophila photoreceptors
por: Jauregui-Lozano, Juan, et al.
Publicado: (2023)

Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis
por: Takaoka, Shohei, et al.
Publicado: (2021)

Blue light induces a neuroprotective gene expression program in Drosophila photoreceptors
por: Hall, Hana, et al.
Publicado: (2018)

Djck1α Is Required for Proper Regeneration and Maintenance of the Medial Tissues in Planarians
por: Huang, Yongding, et al.
Publicado: (2023)

Calreticulin is required for calcium homeostasis and proper pollen tube tip growth in Petunia
por: Suwińska, Anna, et al.
Publicado: (2017)

Quantitative Proteomic and Metabolomic Profiling Reveals Altered Mitochondrial Metabolism and Folate Biosynthesis Pathways in the Aging Drosophila Eye
por: Hall, Hana, et al.
Publicado: (2021)

Balanced Shh signaling is required for proper formation and maintenance of dorsal telencephalic midline structures
por: Himmelstein, Diana S, et al.
Publicado: (2010)

The proteasome regulator PI31 is required for protein homeostasis, synapse maintenance, and neuronal survival in mice
por: Minis, Adi, et al.
Publicado: (2019)

Cytochrome b5 protects photoreceptors from light stress-induced lipid peroxidation and retinal degeneration
por: Chen, Xinping, et al.
Publicado: (2017)

sli is required for proper morphology and migration of sensory neurons in the Drosophila PNS
por: Gonsior, Madison, et al.
Publicado: (2019)

The non-dosage compensated Lsp1α gene of Drosophila melanogaster escapes acetylation by MOF in larval fat body nuclei, but is flanked by two dosage compensated genes
por: Weake, Vikki M, et al.
Publicado: (2007)

Concerted effort of centrosomal and Golgi-derived microtubules is required for proper Golgi complex assembly but not for maintenance
por: Vinogradova, Tatiana, et al.
Publicado: (2012)

The Requirements for the Proper Study of Medicine
Publicado: (1863)

Transcriptome Profiling Identifies Multiplexin as a Target of SAGA Deubiquitinase Activity in Glia Required for Precise Axon Guidance During Drosophila Visual Development
por: Ma, Jingqun, et al.
Publicado: (2016)

The raft-associated protein MAL is required for maintenance of proper axon–glia interactions in the central nervous system
por: Schaeren-Wiemers, Nicole, et al.
Publicado: (2004)

Snap29 Is Dispensable for Self-Renewal Maintenance but Required for Proper Differentiation of Mouse Embryonic Stem Cells
por: Jia, Yumei, et al.
Publicado: (2023)

Autophagy is required for proper cysteine homeostasis in pancreatic cancer through regulation of SLC7A11
por: Mukhopadhyay, Subhadip, et al.
Publicado: (2021)

Epithelial Sel1L is required for the maintenance of intestinal homeostasis
por: Sun, Shengyi, et al.
Publicado: (2016)

ZFP91 is required for the maintenance of regulatory T cell homeostasis and function
por: Wang, Aiting, et al.
Publicado: (2020)

Proper connectivity of Drosophila motion detector neurons requires Atonal function in progenitor cells
por: Oliva, Carlos, et al.
Publicado: (2014)

Otoferlin Is Required for Proper Synapse Maturation and for Maintenance of Inner and Outer Hair Cells in Mouse Models for DFNB9
por: Stalmann, Ursula, et al.
Publicado: (2021)

LRP1 regulates peroxisome biogenesis and cholesterol homeostasis in oligodendrocytes and is required for proper CNS myelin development and repair
por: Lin, Jing-Ping, et al.
Publicado: (2017)

Maintenance of neuronal size gradient in MNTB requires sound-evoked activity
por: Weatherstone, Jessica H., et al.
Publicado: (2016)

MCL1 Is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice
por: Healy, Marc E., et al.
Publicado: (2020)

Prior activity of olfactory receptor neurons is required for proper sensory processing and behavior in Drosophila larvae
por: Utashiro, Nao, et al.
Publicado: (2018)

Bcl-xL Is Required by Primary Hippocampal Neurons for Mitochondrial Motility and Proper Neurite Development
por: Jansen, Joseph, et al.
Publicado: (2022)

NuMA is required for the proper completion of mitosis
Publicado: (1993)

miR393 Is Required for Production of Proper Auxin Signalling Outputs
por: Windels, David, et al.
Publicado: (2014)

Müller glial microRNAs are required for the maintenance of glial homeostasis and retinal architecture
por: Wohl, Stefanie G., et al.
Publicado: (2017)

Macrophages and the maintenance of homeostasis
por: Mosser, David M., et al.
Publicado: (2020)

Internalization is required for proper Wingless signaling in Drosophila melanogaster
por: Seto, Elaine S., et al.
Publicado: (2006)

The Nasopalatine Ducts Are Required for Proper Pheromone Signaling in Mice
por: Levy, Dana Rubi, et al.
Publicado: (2020)

Chiffon triggers global histone H3 acetylation and expression of developmental genes in Drosophila embryos
por: Torres-Zelada, Eliana F., et al.
Publicado: (2022)

Senataxin and R-loops homeostasis: multifaced implications in carcinogenesis
por: Gatti, Veronica, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_j9rijig0see815dajd1bfaef86