Composite Clonal Analysis Reveals Transition of NSCLC Subtypes Through Accumulation of Gene Mutations: A Case Report

We analyzed an EGFR-mutated lung cancer with a pathologic diagnosis of combined large cell neuroendocrine carcinoma with mixed adenocarcinoma subtypes. Targeted next-generation sequencing of each component suggested that mutations in RB1, TP53, and SMAD4 and apparent loss of heterozygosity of TP53 a...

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Detalles Bibliográficos
Autores principales: Ando, Takahiro, Kage, Hidenori, Shinozaki-Ushiku, Aya, Tatsuno, Kenji, Tsutsumi, Shuichi, Nagayama, Kazuhiro, Nakajima, Jun, Kohsaka, Shinji, Miyagawa, Kiyoshi, Aburatani, Hiroyuki, Mano, Hiroyuki, Nagase, Takahide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844245/
https://www.ncbi.nlm.nih.gov/pubmed/35199052
http://dx.doi.org/10.1016/j.jtocrr.2022.100277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844245/
https://www.ncbi.nlm.nih.gov/pubmed/35199052
http://dx.doi.org/10.1016/j.jtocrr.2022.100277

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