Systemic and local immune responses to intraocular AAV vector administration in non-human primates

Positive clinical outcomes in adeno-associated virus (AAV)-mediated retinal gene therapy have often been attributed to the low immunogenicity of AAVs and immune privilege of the eye. However, several recent studies have shown potential for inflammatory responses. The current understanding of the fac...

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Detalles Bibliográficos
Autores principales: Ail, Divya, Ren, Duohao, Brazhnikova, Elena, Nouvel-Jaillard, Céline, Bertin, Stephane, Mirashrafi, Seyed Bagher, Fisson, Sylvain, Dalkara, Deniz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844404/
https://www.ncbi.nlm.nih.gov/pubmed/35229004
http://dx.doi.org/10.1016/j.omtm.2022.01.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844404/
https://www.ncbi.nlm.nih.gov/pubmed/35229004
http://dx.doi.org/10.1016/j.omtm.2022.01.011

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