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De novo serine synthesis regulates chondrocyte proliferation during bone development and repair

The majority of the mammalian skeleton is formed through endochondral ossification starting from a cartilaginous template. Cartilage cells, or chondrocytes, survive, proliferate and synthesize extracellular matrix in an avascular environment, but the metabolic requirements for these anabolic process...

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Detalles Bibliográficos
Autores principales: Stegen, Steve, Loopmans, Shauni, Stockmans, Ingrid, Moermans, Karen, Carmeliet, Peter, Carmeliet, Geert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844408/
https://www.ncbi.nlm.nih.gov/pubmed/35165259
http://dx.doi.org/10.1038/s41413-021-00185-7