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CRISPR/Cas9-induced gene conversion between ATAD3 paralogs
Paralogs and pseudogenes are abundant within the human genome, and can mediate non-allelic homologous recombination (NAHR) or gene conversion events. The ATAD3 locus contains three paralogs situated in tandem, and is therefore prone to NAHR-mediated deletions and duplications associated with severe...
Autores principales: | Yanovsky-Dagan, Shira, Frumkin, Ayala, Lupski, James R., Harel, Tamar |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844715/ https://www.ncbi.nlm.nih.gov/pubmed/35199044 http://dx.doi.org/10.1016/j.xhgg.2022.100092 |
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