An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase

Most tumor cells reactivate telomerase to ensure unlimited proliferation, whereas the expression of human telomerase reverse transcriptase (hTERT) is tightly regulated and rate-limiting for telomerase activity maintenance. Several general transcription factors (TFs) have been found in regulating hTE...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Zhifen, Li, Yujing, Xu, Huimin, Xie, Xiaowei, He, Zibin, Lin, Song, Li, Ruofei, Jin, Shouheng, Cui, Jun, Hu, Hai, Liu, Feng, Wu, Su, Ma, Wenbin, Songyang, Zhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844827/
https://www.ncbi.nlm.nih.gov/pubmed/35198878
http://dx.doi.org/10.1016/j.isci.2022.103813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844827/
https://www.ncbi.nlm.nih.gov/pubmed/35198878
http://dx.doi.org/10.1016/j.isci.2022.103813

Ejemplares similares