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An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase

Most tumor cells reactivate telomerase to ensure unlimited proliferation, whereas the expression of human telomerase reverse transcriptase (hTERT) is tightly regulated and rate-limiting for telomerase activity maintenance. Several general transcription factors (TFs) have been found in regulating hTE...

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Detalles Bibliográficos
Autores principales:	Zhou, Zhifen, Li, Yujing, Xu, Huimin, Xie, Xiaowei, He, Zibin, Lin, Song, Li, Ruofei, Jin, Shouheng, Cui, Jun, Hu, Hai, Liu, Feng, Wu, Su, Ma, Wenbin, Songyang, Zhou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844827/ https://www.ncbi.nlm.nih.gov/pubmed/35198878 http://dx.doi.org/10.1016/j.isci.2022.103813

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