SARS-CoV-2 Variants Increase Kinetic Stability of Open Spike Conformations as an Evolutionary Strategy

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) harbor mutations in the spike (S) glycoprotein that confer more efficient transmission and dampen the efficacy of COVID-19 vaccines and antibody therapies. S mediates virus entry and is the primary target for ant...

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Detalles Bibliográficos
Autores principales: Yang, Ziwei, Han, Yang, Ding, Shilei, Shi, Wei, Zhou, Tongqing, Finzi, Andrés, Kwong, Peter D., Mothes, Walther, Lu, Maolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844933/
https://www.ncbi.nlm.nih.gov/pubmed/35164561
http://dx.doi.org/10.1128/mbio.03227-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844933/
https://www.ncbi.nlm.nih.gov/pubmed/35164561
http://dx.doi.org/10.1128/mbio.03227-21

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