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Hypophosphorylated pRb knock‐in mice exhibit hallmarks of aging and vitamin C‐preventable diabetes
Despite extensive analysis of pRB phosphorylation in vitro, how this modification influences development and homeostasis in vivo is unclear. Here, we show that homozygous Rb(∆K4) and Rb(∆K7) knock‐in mice, in which either four or all seven phosphorylation sites in the C‐terminal region of pRb, respe...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844977/ https://www.ncbi.nlm.nih.gov/pubmed/35023164 http://dx.doi.org/10.15252/embj.2020106825 |