Hypophosphorylated pRb knock‐in mice exhibit hallmarks of aging and vitamin C‐preventable diabetes

Despite extensive analysis of pRB phosphorylation in vitro, how this modification influences development and homeostasis in vivo is unclear. Here, we show that homozygous Rb(∆K4) and Rb(∆K7) knock‐in mice, in which either four or all seven phosphorylation sites in the C‐terminal region of pRb, respe...

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Detalles Bibliográficos
Autores principales: Jiang, Zhe, Li, Huiqin, Schroer, Stephanie A, Voisin, Veronique, Ju, YoungJun, Pacal, Marek, Erdmann, Natalie, Shi, Wei, Chung, Philip E D, Deng, Tao, Chen, Nien‐Jung, Ciavarra, Giovanni, Datti, Alessandro, Mak, Tak W, Harrington, Lea, Dick, Frederick A, Bader, Gary D, Bremner, Rod, Woo, Minna, Zacksenhaus, Eldad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844977/
https://www.ncbi.nlm.nih.gov/pubmed/35023164
http://dx.doi.org/10.15252/embj.2020106825

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