Analysis of nucleotide insertion opposite urea and translesion synthesis across urea by DNA polymerases

ABSTRACT: Urea (Ua) is produced in DNA as the result of oxidative damage to thymine and guanine. It was previously reported that Klenow fragment (Kf) exo(−) incorporated dATP opposite Ua, and that DNA polymerase β was blocked by Ua. We report here the following nucleotide incorporations opposite Ua...

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Detalles Bibliográficos
Autores principales: Kawada, Taishu, Kino, Katsuhito, Tokorodani, Kyousuke, Anabuki, Ryuto, Morikawa, Masayuki, Kobayashi, Takanobu, Ohara, Kazuaki, Ohshima, Takayuki, Miyazawa, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8845263/
https://www.ncbi.nlm.nih.gov/pubmed/35168664
http://dx.doi.org/10.1186/s41021-022-00236-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8845263/
https://www.ncbi.nlm.nih.gov/pubmed/35168664
http://dx.doi.org/10.1186/s41021-022-00236-3

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