Lineage-specific silencing of PSAT1 induces serine auxotrophy and sensitivity to dietary serine starvation in luminal breast tumors

A major challenge of targeting metabolism for cancer therapy is pathway redundancy, in which multiple sources of critical nutrients can limit the effectiveness of some metabolism-targeted therapies. Here, we analyze lineage-dependent gene expression in human breast tumors to identify differences in...

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Detalles Bibliográficos
Autores principales: Choi, Bo-Hyun, Rawat, Vipin, Högström, Jenny, Burns, Philippa A., Conger, Kelly O., Ozgurses, Mete Emir, Patel, Jaymin M., Mehta, Tejas S., Warren, Angelica, Selfors, Laura M., Muranen, Taru, Coloff, Jonathan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8845302/
https://www.ncbi.nlm.nih.gov/pubmed/35045283
http://dx.doi.org/10.1016/j.celrep.2021.110278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8845302/
https://www.ncbi.nlm.nih.gov/pubmed/35045283
http://dx.doi.org/10.1016/j.celrep.2021.110278

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