Identification of a conserved drug binding pocket in TMEM16 proteins

The TMEM16 family of calcium-activated membrane proteins includes ten mammalian paralogs (TMEM16A-K) playing distinct physiological roles with some implicated in cancer and airway diseases. Their modulators with therapeutic potential include 1PBC, a potent inhibitor with anti-tumoral properties, and...

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Detalles Bibliográficos
Autores principales: Cheng, Yifan, Feng, Shengjie, Puchades, Cristina, Ko, Juyeon, Figueroa, Eric, Chen, Yifei, Wu, Hao, Gu, Shuo, Han, Tina, Li, Junrui, Ho, Brandon, Shoichet, Brian, Jan, Yuh Nung, Jan, Lily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8845511/
https://www.ncbi.nlm.nih.gov/pubmed/35169791
http://dx.doi.org/10.21203/rs.3.rs-1296933/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8845511/
https://www.ncbi.nlm.nih.gov/pubmed/35169791
http://dx.doi.org/10.21203/rs.3.rs-1296933/v1

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