Cargando…

Intron-Retention Neoantigen Load Predicts Favorable Prognosis in Pancreatic Cancer

High tumor mutation burden (TMB) in many cancer types is associated with the production of tumor-specific neoantigens, a favorable outcome and response to immune checkpoint blockade (ICB) therapy. Besides mutation-derived neoantigens, aberrant intron retention also produces tumor neopeptides that co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dong, Chuanpeng, Reiter, Jill L., Dong, Edward, Wang, Yue, Lee, Kelvin P., Lu, Xiongbin, Liu, Yunlong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer Health 2022
Materias:	ORIGINAL REPORTS
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846286/ https://www.ncbi.nlm.nih.gov/pubmed/35148169 http://dx.doi.org/10.1200/CCI.21.00124

Ejemplares similares

Intron retention-induced neoantigen load correlates with unfavorable prognosis in multiple myeloma
por: Dong, Chuanpeng, et al.
Publicado: (2021)

Bioinformatics detection of modulators controlling splicing factor‐dependent intron retention in the human brain
por: Chen, Steven X., et al.
Publicado: (2022)

Highly robust model of transcription regulator activity predicts breast cancer overall survival
por: Dong, Chuanpeng, et al.
Publicado: (2020)

Genetic Regulation of Human isomiR Biogenesis
por: Jiang, Guanglong, et al.
Publicado: (2023)

RegSNPs-intron: a computational framework for predicting pathogenic impact of intronic single nucleotide variants
por: Lin, Hai, et al.
Publicado: (2019)

Neoantigen quality predicts immunoediting in survivors of pancreatic cancer
por: Łuksza, Marta, et al.
Publicado: (2022)

T lymphocyte recognition of peptide antigens: evidence favoring the formation of neoantigenic determinants
Publicado: (1982)

Characterization of Neoantigen Load Subgroups in Gynecologic and Breast Cancers
por: Zhu, Yue, et al.
Publicado: (2020)

Intron retention is a robust marker of intertumoral heterogeneity in pancreatic ductal adenocarcinoma
por: Tan, Daniel J., et al.
Publicado: (2020)

Toll-like receptor 1 predicts favorable prognosis in pancreatic cancer
por: Lanki, Mira, et al.
Publicado: (2019)

Intron Retention as a Mode for RNA-Seq Data Analysis
por: Zheng, Jian-Tao, et al.
Publicado: (2020)

Neoantigen load and HLA-class I expression identify a subgroup of tumors with a T-cell-inflamed phenotype and favorable prognosis in homologous recombination-proficient high-grade serous ovarian carcinoma
por: Matsushita, Hirokazu, et al.
Publicado: (2020)

Transcription factor expression as a predictor of colon cancer prognosis: a machine learning practice
por: Liu, Jiannan, et al.
Publicado: (2020)

Sequence features responsible for intron retention in human
por: Sakabe, Noboru Jo, et al.
Publicado: (2007)

The global landscape of intron retentions in lung adenocarcinoma
por: Zhang, Qu, et al.
Publicado: (2014)

IntEREst: intron-exon retention estimator
por: Oghabian, Ali, et al.
Publicado: (2018)

Intron retention is a source of neoepitopes in cancer
por: Smart, Alicia C., et al.
Publicado: (2018)

Increased intron retention is linked to Alzheimer’s disease
por: Ong, Chin-Tong, et al.
Publicado: (2019)

Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma
por: Lauss, Martin, et al.
Publicado: (2017)

Position-specific intron retention is mediated by the histone methyltransferase SDG725
por: Wei, Gang, et al.
Publicado: (2018)

Exploiting the neoantigen landscape for immunotherapy of pancreatic ductal adenocarcinoma
por: Bailey, Peter, et al.
Publicado: (2016)

Neoantigen Quantity and Quality in Relation to Pancreatic Cancer Survival
por: Levink, Iris J. M., et al.
Publicado: (2022)

Prevalent intron retention fine‐tunes gene expression and contributes to cellular senescence
por: Yao, Jun, et al.
Publicado: (2020)

Construction and validation of an immunoediting-based optimized neoantigen load (ioTNL) model to predict the response and prognosis of immune checkpoint therapy in various cancers
por: Su, Xiaofan, et al.
Publicado: (2022)

Regulation of Retention of FosB Intron 4 by PTB
por: Marinescu, Victor, et al.
Publicado: (2007)

Intron Retention and TE Exonization Events in ZRANB2
por: Park, Sang-Je, et al.
Publicado: (2012)

Widespread intron retention in mammals functionally tunes transcriptomes
por: Braunschweig, Ulrich, et al.
Publicado: (2014)

Widespread intron retention diversifies most cancer transcriptomes
por: Dvinge, Heidi, et al.
Publicado: (2015)

Intron retention-dependent gene regulation in Cryptococcus neoformans
por: Gonzalez-Hilarion, Sara, et al.
Publicado: (2016)

Intron retention enhances gene regulatory complexity in vertebrates
por: Schmitz, Ulf, et al.
Publicado: (2017)

The changing paradigm of intron retention: regulation, ramifications and recipes
por: Monteuuis, Geoffray, et al.
Publicado: (2019)

Reactive astrocytes in ALS display diminished intron retention
por: Ziff, Oliver J, et al.
Publicado: (2021)

Towards resolution of the intron retention paradox in breast cancer
por: Shah, Jaynish S., et al.
Publicado: (2022)

iREAD: a tool for intron retention detection from RNA-seq data
por: Li, Hong-Dong, et al.
Publicado: (2020)

Neoantigen‐based cancer vaccination using chimeric RNA‐loaded dendritic cell‐derived extracellular vesicles
por: Xiong, Xiao, et al.
Publicado: (2022)

Structure Based Prediction of Neoantigen Immunogenicity
por: Riley, Timothy P., et al.
Publicado: (2019)

Tumor neoantigens: Novel strategies for application of cancer immunotherapy
por: GUAN, HANYANG, et al.
Publicado: (2023)

SpliceAI-10k calculator for the prediction of pseudoexonization, intron retention, and exon deletion
por: Canson, Daffodil M, et al.
Publicado: (2023)

Neoantigens retention in patient derived xenograft models mediates autologous T cells activation in ovarian cancer
por: Want, Muzamil Yaqub, et al.
Publicado: (2019)

Minor intron splicing revisited: identification of new minor intron-containing genes and tissue-dependent retention and alternative splicing of minor introns
por: Olthof, Anouk M., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_2147sk553spop36n21u978hhkn