Antivirulence Bispecific Monoclonal Antibody-Mediated Protection against Pseudomonas aeruginosa Ventilator-Associated Pneumonia in a Rabbit Model

Ventilator-associated pneumonia is an important clinical manifestation of the nosocomial pathogen Pseudomonas aeruginosa. We characterized the correlates of protection with MEDI3902, a bispecific human IgG1 monoclonal antibody that targets the P. aeruginosa type 3 secretion system PcrV protein and t...

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Detalles Bibliográficos
Autores principales: Aguiar-Alves, Fábio, Le, Hoan N., Tran, Vuvi G., Gras, Emmanuelle, Vu, Trang T. T., Dong, Oliver X., Quetz, Josiane Silva, Cheng, Lily I., Yu, Li, Sellman, Bret R., Stover, Charles K., DiGiandomenico, Antonio, Diep, Binh An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846318/
https://www.ncbi.nlm.nih.gov/pubmed/34902264
http://dx.doi.org/10.1128/aac.02022-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846318/
https://www.ncbi.nlm.nih.gov/pubmed/34902264
http://dx.doi.org/10.1128/aac.02022-21

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