The Ultrabroad-Spectrum Beta-Lactamase Inhibitor QPX7728 Restores the Potency of Multiple Oral Beta-Lactam Antibiotics against Beta-Lactamase-Producing Strains of Resistant Enterobacterales

QPX7728 is a cyclic boronate ultrabroad-spectrum beta-lactamase inhibitor, with potent activity against both serine beta-lactamases and metallo-beta-lactamases. QPX7728 can be delivered systemically by the intravenous (i.v.) or oral route of administration. Oral beta-lactam antibiotics alone or in c...

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Detalles Bibliográficos
Autores principales: Lomovskaya, Olga, Rubio-Aparicio, Debora, Tsivkovski, Ruslan, Loutit, Jeff, Dudley, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846479/
https://www.ncbi.nlm.nih.gov/pubmed/34902261
http://dx.doi.org/10.1128/aac.02168-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846479/
https://www.ncbi.nlm.nih.gov/pubmed/34902261
http://dx.doi.org/10.1128/aac.02168-21

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