Cargando…

Integrated functional and spatial profiling of tumour immune responses induced by immunotherapy: the iPROFILER platform

BACKGROUND: Cancer immunotherapy elicits functional activation and changes in immune cell distribution in cancer. Tumour heterogeneity is a reason for treatment failure but is difficult to capture in experimental settings. This proof-of-principle study describes the integrated functional and digital...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koelzer, V.H., Herzig, P., Zlobec, I., Heinzelmann, V., Lardinois, D., Walseng, E., Rader, C., Mertz, K.D., Zippelius, A., Thommen, D.S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846576/ https://www.ncbi.nlm.nih.gov/pubmed/35174321 http://dx.doi.org/10.1016/j.iotech.2021.100034

Ejemplares similares

A transcriptionally and functionally distinct PD-1(+) CD8(+) T cell pool with predictive potential in non-small cell lung cancer treated with PD-1 blockade
por: Thommen, D.S., et al.
Publicado: (2018)

Multimodal predictors for precision immunotherapy
por: Roelofsen, L.M., et al.
Publicado: (2022)

Fibroblast activation protein-targeted-4-1BB ligand agonist amplifies effector functions of intratumoral T cells in human cancer
por: Trüb, Marta, et al.
Publicado: (2020)

Replicating viral vector platform exploits alarmin signals for potent CD8(+) T cell-mediated tumour immunotherapy
por: Kallert, Sandra M., et al.
Publicado: (2017)

Protocol for ex vivo culture of patient-derived tumor fragments
por: Roelofsen, Lisanne M., et al.
Publicado: (2023)

Grover’s-like drug eruption in a patient with metastatic melanoma under ipilimumab therapy
por: Koelzer, Viktor H., et al.
Publicado: (2016)

Systemic inflammation in a melanoma patient treated with immune checkpoint inhibitors—an autopsy study
por: Koelzer, Viktor H., et al.
Publicado: (2016)

Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy
por: Trefny, Marcel P., et al.
Publicado: (2023)

Evaluation of high-resolution microarray platforms for genomic profiling of bone tumours
por: Kresse, Stine H, et al.
Publicado: (2010)

Deciphering molecular and cellular ex vivo responses to bispecific antibodies PD1-TIM3 and PD1-LAG3 in human tumors
por: Natoli, Marina, et al.
Publicado: (2022)

Effectuality of Cleaning Workers' Training and Cleaning Enterprises' Chemical Health Hazard Risk Profiling
por: Suleiman, Abdulqadir M., et al.
Publicado: (2015)

Integrated Analysis Of Immunotherapy Treated Clear Cell Renal Cell Carcinomas: An Exploratory Study
por: Sobottka, Bettina, et al.
Publicado: (2022)

Tumor Budding in Upper Gastrointestinal Carcinomas
por: Koelzer, Viktor H., et al.
Publicado: (2014)

Update on the current opinion, status and future development of digital pathology in Switzerland in light of COVID-19
por: Koelzer, Viktor Hendrik, et al.
Publicado: (2022)

Precision immunoprofiling by image analysis and artificial intelligence
por: Koelzer, Viktor H., et al.
Publicado: (2018)

Gene expression profiling of human ovarian tumours
por: Biade, S, et al.
Publicado: (2006)

Geographic analysis of RKIP expression and its clinical relevance in colorectal cancer
por: Koelzer, V H, et al.
Publicado: (2013)

Tumour budding and its clinical implications in gastrointestinal cancers
por: Zlobec, Inti, et al.
Publicado: (2020)

Cytokeratin‐based assessment of tumour budding in colorectal cancer: analysis in stage II patients and prospective diagnostic experience
por: Koelzer, Viktor H, et al.
Publicado: (2017)

Two distinct immunopathological profiles in autopsy lungs of COVID-19
por: Nienhold, Ronny, et al.
Publicado: (2020)

Intratumoural budding (ITB) in preoperative biopsies predicts the presence of lymph node and distant metastases in colon and rectal cancer patients
por: Zlobec, I, et al.
Publicado: (2014)

Gene expression profiling to predict responsiveness to immunotherapy
por: Jamieson, Nigel B., et al.
Publicado: (2016)

Next-generation tissue microarray (ngTMA) increases the quality of biomarker studies: an example using CD3, CD8, and CD45RO in the tumor microenvironment of six different solid tumor types
por: Zlobec, Inti, et al.
Publicado: (2013)

PD-1(T) TILs as a Predictive Biomarker for Clinical Benefit to PD-1 Blockade in Patients with Advanced NSCLC
por: Hummelink, Karlijn, et al.
Publicado: (2022)

PERSONALITY PROFILES OF CORONARY CASES
por: Saldanha, D., et al.
Publicado: (1993)

ORAL CONTRACEPTIVES AND POST-MOLAR TROPHOBLASTIC TUMOURS
por: Bagshawe, K.D., et al.
Publicado: (1980)

Tertiary Lymphoid Structures as a Predictive Biomarker of Response to Cancer Immunotherapies
por: Trüb, Marta, et al.
Publicado: (2021)

Immunophenotypic profile of tumor buds in breast cancer
por: Laedrach, C., et al.
Publicado: (2017)

The expression profile for the tumour suppressor gene PTEN and associated polymorphic markers
por: Hamilton, J A, et al.
Publicado: (2000)

Rationalizing the pathway to personalized neoadjuvant immunotherapy: the Lombard Street Approach
por: Versluis, Judith M, et al.
Publicado: (2020)

Loss of tapasin correlates with diminished CD8(+) T-cell immunity and prognosis in colorectal cancer
por: Sokol, Lena, et al.
Publicado: (2015)

Heterogeneity analysis of Metastasis Associated in Colon Cancer 1 (MACC1) for survival prognosis of colorectal cancer patients: a retrospective cohort study
por: Koelzer, Viktor H, et al.
Publicado: (2015)

Molecular Profile Sensitization to House Dust Mites as an Important Aspect for Predicting the Efficiency of Allergen Immunotherapy
por: Rodinkova, Victoria V., et al.
Publicado: (2022)

Tissue metabolite profiles for the characterisation of paediatric cerebellar tumours
por: Bennett, Christopher D., et al.
Publicado: (2018)

Tumour microenvironment‐based molecular profiling reveals ideal candidates for high‐grade serous ovarian cancer immunotherapy
por: Lu, Xiaofan, et al.
Publicado: (2021)

Mutational profiling of low‐grade gliomas identifies prognosis and immunotherapy‐related biomarkers and tumour immune microenvironment characteristics
por: Lin, Wen‐wen, et al.
Publicado: (2021)

Tumour budding: a promising parameter in colorectal cancer
por: Lugli, A, et al.
Publicado: (2012)

A Chemical Acetylation-Based Mass Spectrometry Platform for Histone Methylation Profiling
por: Zappacosta, Francesca, et al.
Publicado: (2021)

Microarray based expression profiling of BRCA1 mutated human tumours using a breast-specific platform to identify a profile of BRCA1 deficiency
por: Lamers, E, et al.
Publicado: (2010)

ISOpureR: an R implementation of a computational purification algorithm of mixed tumour profiles
por: Anghel, Catalina V, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_bjd8iqqb7a17g4s8fkj6ug3cj6