Repression of hypoxia-inducible factor-1 contributes to increased mitochondrial reactive oxygen species production in diabetes

BACKGROUND: Excessive production of mitochondrial reactive oxygen species (ROS) is a central mechanism for the development of diabetes complications. Recently, hypoxia has been identified to play an additional pathogenic role in diabetes. In this study, we hypothesized that ROS overproduction was se...

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Detalles Bibliográficos
Autores principales: Zheng, Xiaowei, Narayanan, Sampath, Xu, Cheng, Eliasson Angelstig, Sofie, Grünler, Jacob, Zhao, Allan, Di Toro, Alessandro, Bernardi, Luciano, Mazzone, Massimiliano, Carmeliet, Peter, Del Sole, Marianna, Solaini, Giancarlo, Forsberg, Elisabete A, Zhang, Ao, Brismar, Kerstin, Schiffer, Tomas A, Rajamand Ekberg, Neda, Botusan, Ileana Ruxandra, Palm, Fredrik, Catrina, Sergiu-Bogdan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846593/
https://www.ncbi.nlm.nih.gov/pubmed/35164902
http://dx.doi.org/10.7554/eLife.70714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846593/
https://www.ncbi.nlm.nih.gov/pubmed/35164902
http://dx.doi.org/10.7554/eLife.70714

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