Translating in vitro CFTR rescue into small molecule correctors for cystic fibrosis using the Library of Integrated Network‐based Cellular Signatures drug discovery platform

Cystic fibrosis (CF) is a lethal autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The common ΔF508‐CFTR mutation results in protein misfolding and proteasomal degradation. If ΔF508‐CFTR trafficks to the cell surface, its anion ch...

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Detalles Bibliográficos
Autores principales: Strub, Matthew D., Ramachandran, Shyam, Boudko, Dmitri Y., Meleshkevitch, Ella A., Pezzulo, Alejandro A., Subramanian, Aravind, Liberzon, Arthur, Bridges, Robert J., McCray, Paul B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846631/
https://www.ncbi.nlm.nih.gov/pubmed/34877817
http://dx.doi.org/10.1002/psp4.12751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846631/
https://www.ncbi.nlm.nih.gov/pubmed/34877817
http://dx.doi.org/10.1002/psp4.12751

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