Physiologically‐based pharmacokinetic modeling to predict CYP3A4‐mediated drug‐drug interactions of finerenone

Finerenone is a nonsteroidal, selective mineralocorticoid receptor antagonist that recently demonstrated its efficacy to delay chronic kidney disease (CKD) progression and reduce cardiovascular events in patients with CKD and type 2 diabetes. Here, we report the development of a physiologically‐base...

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Detalles Bibliográficos
Autores principales: Wendl, Thomas, Frechen, Sebastian, Gerisch, Michael, Heinig, Roland, Eissing, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846632/
https://www.ncbi.nlm.nih.gov/pubmed/34783193
http://dx.doi.org/10.1002/psp4.12746

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846632/
https://www.ncbi.nlm.nih.gov/pubmed/34783193
http://dx.doi.org/10.1002/psp4.12746

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