Physiologically‐based pharmacokinetic modeling of oxcarbazepine and levetiracetam during adjunctive antiepileptic therapy in children and adolescents

Oxcarbazepine (OXZ) and levetiracetam (LEV) are two new generation anti‐epileptic drugs, often co‐administered in children with enzyme‐inducing antiepileptic drugs (EIAEDs). The anti‐epileptic effect of OXZ and LEV are linked to the exposure of OXZ’s active metabolite 10‐monohydroxy derivative (MHD)...

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Detalles Bibliográficos
Autores principales: Sinha, Jaydeep, Karatza, Eleni, Gonzalez, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846633/
https://www.ncbi.nlm.nih.gov/pubmed/34816634
http://dx.doi.org/10.1002/psp4.12750

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846633/
https://www.ncbi.nlm.nih.gov/pubmed/34816634
http://dx.doi.org/10.1002/psp4.12750

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