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Metformin induces insulin secretion by preserving pancreatic aquaporin 7 expression in type 2 diabetes mellitus
In the presence of metformin, the c‐Jun‐NH2‐terminal kinase and p38 pathways in β‐cells are inhibited, resulting in preserved aquaporin 7 expression and improved glycerol influx, thus maintaining insulin secretion.[Image: see text]
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847123/ https://www.ncbi.nlm.nih.gov/pubmed/34779127 http://dx.doi.org/10.1111/jdi.13709 |
| Sumario: | In the presence of metformin, the c‐Jun‐NH2‐terminal kinase and p38 pathways in β‐cells are inhibited, resulting in preserved aquaporin 7 expression and improved glycerol influx, thus maintaining insulin secretion.[Image: see text] |
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