Metformin induces insulin secretion by preserving pancreatic aquaporin 7 expression in type 2 diabetes mellitus

In the presence of metformin, the c‐Jun‐NH2‐terminal kinase and p38 pathways in β‐cells are inhibited, resulting in preserved aquaporin 7 expression and improved glycerol influx, thus maintaining insulin secretion.[Image: see text]

Detalles Bibliográficos
Autores principales: Kimura, Tomohiko, Kaneto, Hideaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847123/
https://www.ncbi.nlm.nih.gov/pubmed/34779127
http://dx.doi.org/10.1111/jdi.13709
_version_ 1784651982578909184
author Kimura, Tomohiko
Kaneto, Hideaki
author_facet Kimura, Tomohiko
Kaneto, Hideaki
author_sort Kimura, Tomohiko
collection PubMed
description In the presence of metformin, the c‐Jun‐NH2‐terminal kinase and p38 pathways in β‐cells are inhibited, resulting in preserved aquaporin 7 expression and improved glycerol influx, thus maintaining insulin secretion.[Image: see text]
format Online
Article
Text
id pubmed-8847123
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-88471232022-02-25 Metformin induces insulin secretion by preserving pancreatic aquaporin 7 expression in type 2 diabetes mellitus Kimura, Tomohiko Kaneto, Hideaki J Diabetes Investig Commentary In the presence of metformin, the c‐Jun‐NH2‐terminal kinase and p38 pathways in β‐cells are inhibited, resulting in preserved aquaporin 7 expression and improved glycerol influx, thus maintaining insulin secretion.[Image: see text] John Wiley and Sons Inc. 2021-12-03 2022-02 /pmc/articles/PMC8847123/ /pubmed/34779127 http://dx.doi.org/10.1111/jdi.13709 Text en © 2021 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Commentary
Kimura, Tomohiko
Kaneto, Hideaki
Metformin induces insulin secretion by preserving pancreatic aquaporin 7 expression in type 2 diabetes mellitus
title Metformin induces insulin secretion by preserving pancreatic aquaporin 7 expression in type 2 diabetes mellitus
title_full Metformin induces insulin secretion by preserving pancreatic aquaporin 7 expression in type 2 diabetes mellitus
title_fullStr Metformin induces insulin secretion by preserving pancreatic aquaporin 7 expression in type 2 diabetes mellitus
title_full_unstemmed Metformin induces insulin secretion by preserving pancreatic aquaporin 7 expression in type 2 diabetes mellitus
title_short Metformin induces insulin secretion by preserving pancreatic aquaporin 7 expression in type 2 diabetes mellitus
title_sort metformin induces insulin secretion by preserving pancreatic aquaporin 7 expression in type 2 diabetes mellitus
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847123/
https://www.ncbi.nlm.nih.gov/pubmed/34779127
http://dx.doi.org/10.1111/jdi.13709
work_keys_str_mv AT kimuratomohiko metformininducesinsulinsecretionbypreservingpancreaticaquaporin7expressionintype2diabetesmellitus
AT kanetohideaki metformininducesinsulinsecretionbypreservingpancreaticaquaporin7expressionintype2diabetesmellitus

Ejemplares similares