A small molecule high throughput screening platform to profile conformational properties of nascent, ribosome-bound proteins

Genetic mutations cause a wide spectrum of human disease by disrupting protein folding, both during and after synthesis. Transient de-novo folding intermediates therefore represent potential drug targets for pharmacological correction of protein folding disorders. Here we develop a FRET-based high-t...

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Detalles Bibliográficos
Autores principales: Shishido, Hideki, Yoon, Jae Seok, Skach, William R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847357/
https://www.ncbi.nlm.nih.gov/pubmed/35169219
http://dx.doi.org/10.1038/s41598-022-06456-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847357/
https://www.ncbi.nlm.nih.gov/pubmed/35169219
http://dx.doi.org/10.1038/s41598-022-06456-5

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