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A small molecule high throughput screening platform to profile conformational properties of nascent, ribosome-bound proteins
Genetic mutations cause a wide spectrum of human disease by disrupting protein folding, both during and after synthesis. Transient de-novo folding intermediates therefore represent potential drug targets for pharmacological correction of protein folding disorders. Here we develop a FRET-based high-t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847357/ https://www.ncbi.nlm.nih.gov/pubmed/35169219 http://dx.doi.org/10.1038/s41598-022-06456-5 |