UBE2T-mediated Akt ubiquitination and Akt/β-catenin activation promotes hepatocellular carcinoma development by increasing pyrimidine metabolism

The oncogene protein ubiquitin-conjugating enzyme E2T (UBE2T) is reported to be upregulated in hepatocellular carcinoma (HCC) and correlated with poor clinical outcomes of HCC patients. However, the underlying mechanism by which UBE2T exerts its oncogenic function in HCC remains largely unexplored....

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Detalles Bibliográficos
Autores principales: Zhu, Zhenru, Cao, Chuanhui, Zhang, Dongyan, Zhang, Zhihong, Liu, Li, Wu, Dehua, Sun, Jingyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847552/
https://www.ncbi.nlm.nih.gov/pubmed/35169125
http://dx.doi.org/10.1038/s41419-022-04596-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847552/
https://www.ncbi.nlm.nih.gov/pubmed/35169125
http://dx.doi.org/10.1038/s41419-022-04596-0

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