Tofacitinib and metformin reduce the dermal thickness and fibrosis in mouse model of systemic sclerosis

Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway is important in the process of inflammation and fibrosis. The adenosine 5′-monophosphate-activated protein kinase (AMPK) enzyme can affect JAK/STAT pathway. Tofacitinib is a pan-JAK inhibitör. Metformin activates AMPK...

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Detalles Bibliográficos
Autores principales: Karatas, Ahmet, Oz, Burak, Celik, Cigdem, Akar, Zeynel Abidin, Akkoc, Ramazan Fazil, Etem, Ebru Onalan, Dagli, Adile Ferda, Koca, Suleyman Serdar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847622/
https://www.ncbi.nlm.nih.gov/pubmed/35169250
http://dx.doi.org/10.1038/s41598-022-06581-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847622/
https://www.ncbi.nlm.nih.gov/pubmed/35169250
http://dx.doi.org/10.1038/s41598-022-06581-1

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