The lncRNA TCONS_00021785/miR-21-5p/Trim33 axis regulates VMP1-mediated zymophagy, reduces the activation of trypsinogen, and promotes acinar cell recovery

In the early stage of acute pancreatitis, trypsinogen in acinar cells is activated, and the cells clear trypsin through zymophagy to avoid damage. Studies have shown that the substrate of zymophagy is ubiquitinated pancreatin, but the mechanism of pancreatin ubiquitination and the regulatory mechani...

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Detalles Bibliográficos
Autores principales: Wang, Qiang, Yu, Jingjing, Gao, Wenqi, Sun, Yuanyuan, Liu, Xuxu, Lv, Zhenyi, Li, Long, Xue, Dongbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847645/
https://www.ncbi.nlm.nih.gov/pubmed/35169128
http://dx.doi.org/10.1038/s41420-022-00862-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847645/
https://www.ncbi.nlm.nih.gov/pubmed/35169128
http://dx.doi.org/10.1038/s41420-022-00862-4

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