Quadruple Target Evaluation of Diversity-Optimized Halogen-Enriched Fragments (HEFLibs) Reveals Substantial Ligand Efficiency for AP2-Associated Protein Kinase 1 (AAK1)

Fragment-based drug discovery is one of the most utilized approaches for the identification of novel weakly binding ligands, by efficiently covering a wide chemical space with rather few compounds and by allowing more diverse binding modes to be found. This approach has led to various clinical candi...

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Detalles Bibliográficos
Autores principales: Dammann, Marcel, Kramer, Markus, Zimmermann, Markus O., Boeckler, Frank M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847695/
https://www.ncbi.nlm.nih.gov/pubmed/35186897
http://dx.doi.org/10.3389/fchem.2021.815567

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847695/
https://www.ncbi.nlm.nih.gov/pubmed/35186897
http://dx.doi.org/10.3389/fchem.2021.815567

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