CRISPR-Cas9-mediated gene disruption of HIV-1 co-receptors confers broad resistance to infection in human T cells and humanized mice

In this preclinical study, we evaluated the efficacy and feasibility of creating broad human immunodeficiency virus (HIV) resistance by simultaneously disrupting the human CCR5 and CXCR4 genes, which encode cellular co-receptors required for HIV-1 infection. Using a clinically scalable system for tr...

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Detalles Bibliográficos
Autores principales: Li, Shasha, Holguin, Leo, Burnett, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847835/
https://www.ncbi.nlm.nih.gov/pubmed/35229006
http://dx.doi.org/10.1016/j.omtm.2022.01.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847835/
https://www.ncbi.nlm.nih.gov/pubmed/35229006
http://dx.doi.org/10.1016/j.omtm.2022.01.012

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