STAT3 is required for Smo‐dependent signaling and mediates Smo‐targeted treatment resistance and tumorigenesis in Shh medulloblastoma

Sonic hedgehog (Shh)‐driven medulloblastoma (Shh MB) cells are dependent on constitutive Shh signaling, but targeted treatment of Shh MB has been ineffective due to drug resistance. The purpose of this study was to address the critical role of signal transducer and activator of transcription 3 (STAT...

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Detalles Bibliográficos
Autores principales: Yuan, Liangping, Zhang, Hongying, Liu, Jingbo, Malhotra, Anshu, Dey, Abhinav, Yu, Bing, Jella, Kishore Kumar, McSwain, Leon F., Schniederjan, Matthew J., MacDonald, Tobey J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847987/
https://www.ncbi.nlm.nih.gov/pubmed/34482626
http://dx.doi.org/10.1002/1878-0261.13097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847987/
https://www.ncbi.nlm.nih.gov/pubmed/34482626
http://dx.doi.org/10.1002/1878-0261.13097

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