Cargando…
The signal transducer CD24 suppresses the germ cell program and promotes an ectodermal rather than mesodermal cell fate in embryonal carcinomas
Testicular germ cell tumors (GCTs) are stratified into seminomas and nonseminomas. Seminomas share many histological and molecular features with primordial germ cells, whereas the nonseminoma stem cell population—embryonal carcinoma (EC)—is pluripotent and thus able to differentiate into cells of al...
Autores principales: | Skowron, Margaretha A., Becker, Teresa K., Kurz, Lukas, Jostes, Sina, Bremmer, Felix, Fronhoffs, Florian, Funke, Kai, Wakileh, Gamal A., Müller, Melanie R., Burmeister, Aaron, Lenz, Thomas, Stefanski, Anja, Stühler, Kai, Petzsch, Patrick, Köhrer, Karl, Altevogt, Peter, Albers, Peter, Kristiansen, Glen, Schorle, Hubert, Nettersheim, Daniel |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847992/ https://www.ncbi.nlm.nih.gov/pubmed/34293822 http://dx.doi.org/10.1002/1878-0261.13066 |
Ejemplares similares
-
Therapeutical interference with the epigenetic landscape of germ cell tumors: a comparative drug study and new mechanistical insights
por: Müller, Melanie R., et al.
Publicado: (2022) -
Deciphering the molecular effects of romidepsin on germ cell tumours: DHRS2 is involved in cell cycle arrest but not apoptosis or induction of romidepsin effectors
por: Nettersheim, Daniel, et al.
Publicado: (2018) -
CDK4/6 inhibition presents as a therapeutic option for paediatric and adult germ cell tumours and induces cell cycle arrest and apoptosis via canonical and non-canonical mechanisms
por: Skowron, Margaretha A., et al.
Publicado: (2020) -
Establishment and Evaluation of Dual HDAC/BET Inhibitors as Therapeutic Options for Germ Cell Tumors and Other Urological Malignancies
por: Burmeister, Aaron, et al.
Publicado: (2022) -
Profiling the 3D interaction between germ cell tumors and microenvironmental cells at the transcriptome and secretome level
por: Skowron, Margaretha A., et al.
Publicado: (2022)