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Effect of imputation on gene network reconstruction from single-cell RNA-seq data

Despite the advances in single-cell transcriptomics, the reconstruction of gene regulatory networks remains challenging. Both the large amount of zero counts in experimental data and the lack of a consensus preprocessing pipeline for single-cell RNA sequencing (scRNA-seq) data make it hard to infer...

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Detalles Bibliográficos
Autores principales: Ly, Lam-Ha, Vingron, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848013/
https://www.ncbi.nlm.nih.gov/pubmed/35199064
http://dx.doi.org/10.1016/j.patter.2021.100414