Novel mechanistic insights into the role of Mer2 as the keystone of meiotic DNA break formation

In meiosis, DNA double-strand break (DSB) formation by Spo11 initiates recombination and enables chromosome segregation. Numerous factors are required for Spo11 activity, and couple the DSB machinery to the development of a meiosis-specific ‘axis-tethered loop’ chromosome organisation. Through in vi...

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Detalles Bibliográficos
Autores principales: Rousová, Dorota, Nivsarkar, Vaishnavi, Altmannova, Veronika, Raina, Vivek B, Funk, Saskia K, Liedtke, David, Janning, Petra, Müller, Franziska, Reichle, Heidi, Vader, Gerben, Weir, John R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848140/
https://www.ncbi.nlm.nih.gov/pubmed/34951404
http://dx.doi.org/10.7554/eLife.72330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848140/
https://www.ncbi.nlm.nih.gov/pubmed/34951404
http://dx.doi.org/10.7554/eLife.72330

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