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High-glucose microenvironment promotes perineural invasion of pancreatic cancer via activation of hypoxia inducible factor 1α

Pancreatic cancer (PC) is one of the most lethal diseases, with a 5-year survival rate of <9%. Perineural invasion (PNI) is a common pathological hallmark of PC and is correlated with a poor prognosis in this disease. Hyperglycemia has been shown to promote the invasion and migration of PC cells;...

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Detalles Bibliográficos
Autores principales: Zhang, Lun, Zhang, Wunai, Zhang, Xin, Min, Yihe, Zhao, Yang, Wang, Baofeng, Li, Wei, Mao, Shuai, Min, Weili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848475/
https://www.ncbi.nlm.nih.gov/pubmed/35088883
http://dx.doi.org/10.3892/or.2022.8275