Pharmacological modulation of Kv1.3 potassium channel selectively triggers pathological B lymphocyte apoptosis in vivo in a genetic CLL model

BACKGROUND: Ion channels are emerging as promising oncological targets. The potassium channels Kv1.3 and IKCa are highly expressed in the plasma membrane and mitochondria of human chronic lymphocytic leukemia (CLL) cells, compared to healthy lymphocytes. In vitro, inhibition of mitoKv1.3 by PAPTP wa...

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Detalles Bibliográficos
Autores principales: Severin, Filippo, Urbani, Andrea, Varanita, Tatiana, Bachmann, Magdalena, Azzolini, Michele, Martini, Veronica, Pizzi, Marco, Tos, Angelo Paolo Dei, Frezzato, Federica, Mattarei, Andrea, Ghia, Paolo, Bertilaccio, Maria Teresa Sabrina, Gulbins, Erich, Paradisi, Cristina, Zoratti, Mario, Semenzato, Gianpietro Carlo, Leanza, Luigi, Trentin, Livio, Szabò, Ildiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848658/
https://www.ncbi.nlm.nih.gov/pubmed/35172855
http://dx.doi.org/10.1186/s13046-022-02249-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848658/
https://www.ncbi.nlm.nih.gov/pubmed/35172855
http://dx.doi.org/10.1186/s13046-022-02249-w

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