Synthesis and evaluation of potent yaku'amide A analogs

Two full-length analogs of the anticancer peptide yaku'amide A (1a) and four partial structures have been synthesized. These analogs were identified by computational studies in which the three E- and Z-ΔIle residues of the natural product were replaced by the more accessible dehydroamino acids...

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Detalles Bibliográficos
Autores principales: Lo, Concordia C. L., Joaquin, Daniel, Moyá, Diego A., Ramos, Alexander, Kastner, David W., White, Stephen M., Christensen, Blake L., Naglich, Joseph G., Degnen, William J., Castle, Steven L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848768/
https://www.ncbi.nlm.nih.gov/pubmed/35308852
http://dx.doi.org/10.1039/d1sc05992k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848768/
https://www.ncbi.nlm.nih.gov/pubmed/35308852
http://dx.doi.org/10.1039/d1sc05992k

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