Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination

Medulloblastoma (MB) is a malignant pediatric brain tumor arising in the cerebellum. Although abnormal GABAergic receptor activation has been described in MB, studies have not yet elucidated the contribution of receptor-independent GABA metabolism to MB pathogenesis. We find primary MB tumors global...

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Detalles Bibliográficos
Autores principales: Martirosian, Vahan, Deshpande, Krutika, Zhou, Hao, Shen, Keyue, Smith, Kyle, Northcott, Paul, Lin, Michelle, Stepanosyan, Vazgen, Das, Diganta, Remsik, Jan, Isakov, Danielle, Boire, Adrienne, De Feyter, Henk, Hurth, Kyle, Li, Shaobo, Wiemels, Joseph, Nakamura, Brooke, Shao, Ling, Danilov, Camelia, Chen, Thomas, Neman, Josh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848833/
https://www.ncbi.nlm.nih.gov/pubmed/34192534
http://dx.doi.org/10.1016/j.celrep.2021.109302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848833/
https://www.ncbi.nlm.nih.gov/pubmed/34192534
http://dx.doi.org/10.1016/j.celrep.2021.109302

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