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Discovery of an NAD(+) analogue with enhanced specificity for PARP1
Among various protein posttranslational modifiers, poly-ADP-ribose polymerase 1 (PARP1) is a key player for regulating numerous cellular processes and events through enzymatic attachments of target proteins with ADP-ribose units donated by nicotinamide adenine dinucleotide (NAD(+)). Human PARP1 is i...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848837/ https://www.ncbi.nlm.nih.gov/pubmed/35308855 http://dx.doi.org/10.1039/d1sc06256e |