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Discovery of an NAD(+) analogue with enhanced specificity for PARP1

Among various protein posttranslational modifiers, poly-ADP-ribose polymerase 1 (PARP1) is a key player for regulating numerous cellular processes and events through enzymatic attachments of target proteins with ADP-ribose units donated by nicotinamide adenine dinucleotide (NAD(+)). Human PARP1 is i...

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Detalles Bibliográficos
Autores principales:	Zhang, Xiao-Nan, Lam, Albert T., Cheng, Qinqin, Courouble, Valentine V., Strutzenberg, Timothy S., Li, Jiawei, Wang, Yiling, Pei, Hua, Stiles, Bangyan L., Louie, Stan G., Griffin, Patrick R., Zhang, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848837/ https://www.ncbi.nlm.nih.gov/pubmed/35308855 http://dx.doi.org/10.1039/d1sc06256e

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