RNA uridyl transferases TUT4/7 differentially regulate miRNA variants depending on the cancer cell type

The human terminal uridyl transferases TUT4 and TUT7 (TUT4/7) catalyze the additions of uridines at the 3′ end of RNAs, including the precursors of the tumor suppressor miRNA let-7 upon recruitment by the oncoprotein LIN28A. As a consequence, let-7 family miRNAs are down-regulated. Disruption of thi...

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Detalles Bibliográficos
Autores principales: Medhi, Ragini, Price, Jonathan, Furlan, Giulia, Gorges, Beronia, Sapetschnig, Alexandra, Miska, Eric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848932/
https://www.ncbi.nlm.nih.gov/pubmed/34949722
http://dx.doi.org/10.1261/rna.078976.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848932/
https://www.ncbi.nlm.nih.gov/pubmed/34949722
http://dx.doi.org/10.1261/rna.078976.121

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