Salicylate metal-binding isosteres as fragments for metalloenzyme inhibition

Metalloenzyme inhibitors typically share a common need to possess a metal-binding pharmacophore (MBP) for binding the active site metal ions. However, MBPs can suffer from physicochemical liabilities, impeding the pharmacological properties and drug-likeliness of inhibitors. To circumvent this, prob...

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Detalles Bibliográficos
Autores principales: Jackl, Moritz K., Seo, Hyeonglim, Karges, Johannes, Kalaj, Mark, Cohen, Seth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849047/
https://www.ncbi.nlm.nih.gov/pubmed/35308862
http://dx.doi.org/10.1039/d1sc06011b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849047/
https://www.ncbi.nlm.nih.gov/pubmed/35308862
http://dx.doi.org/10.1039/d1sc06011b

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