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A dominant tubulin mutation causes cerebellar neurodegeneration in a genetic model of tubulinopathy
Mutations in tubulins cause distinct neurodevelopmental and degenerative diseases termed “tubulinopathies”; however, little is known about the functional requirements of tubulins or how mutations cause cell-specific pathologies. Here, we identify a mutation in the gene Tubb4a that causes degeneratio...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849301/ https://www.ncbi.nlm.nih.gov/pubmed/35171680 http://dx.doi.org/10.1126/sciadv.abf7262 |