Integrated -omics approach reveals persistent DNA damage rewires lipid metabolism and histone hyperacetylation via MYS-1/Tip60

Although DNA damage is intricately linked to metabolism, the metabolic alterations that occur in response to DNA damage are not well understood. We use a DNA repair–deficient model of ERCC1-XPF in Caenorhabditis elegans to gain insights on how genotoxic stress drives aging. Using multi-omic approach...

Descripción completa

Detalles Bibliográficos
Autores principales: Hamsanathan, Shruthi, Anthonymuthu, Tamil, Han, Suhao, Shinglot, Himaly, Siefken, Ella, Sims, Austin, Sen, Payel, Pepper, Hannah L., Snyder, Nathaniel W., Bayir, Hulya, Kagan, Valerian, Gurkar, Aditi U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849393/
https://www.ncbi.nlm.nih.gov/pubmed/35171671
http://dx.doi.org/10.1126/sciadv.abl6083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849393/
https://www.ncbi.nlm.nih.gov/pubmed/35171671
http://dx.doi.org/10.1126/sciadv.abl6083

Ejemplares similares