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Integrated -omics approach reveals persistent DNA damage rewires lipid metabolism and histone hyperacetylation via MYS-1/Tip60

Although DNA damage is intricately linked to metabolism, the metabolic alterations that occur in response to DNA damage are not well understood. We use a DNA repair–deficient model of ERCC1-XPF in Caenorhabditis elegans to gain insights on how genotoxic stress drives aging. Using multi-omic approach...

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Detalles Bibliográficos
Autores principales:	Hamsanathan, Shruthi, Anthonymuthu, Tamil, Han, Suhao, Shinglot, Himaly, Siefken, Ella, Sims, Austin, Sen, Payel, Pepper, Hannah L., Snyder, Nathaniel W., Bayir, Hulya, Kagan, Valerian, Gurkar, Aditi U.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849393/ https://www.ncbi.nlm.nih.gov/pubmed/35171671 http://dx.doi.org/10.1126/sciadv.abl6083

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