KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer

EP300, a transcription coactivator important in proliferation and differentiation, is frequently mutated in diverse cancer types, including small cell lung cancer (SCLC). While these mutations are thought to result in loss of EP300 function, the impact on tumorigenesis remains largely unknown. Here,...

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Detalles Bibliográficos
Autores principales: Kim, Kee-Beom, Kabra, Ashish, Kim, Dong-Wook, Xue, Yongming, Huang, Yuanjian, Hou, Pei-Chi, Zhou, Yunpeng, Miranda, Leilani J., Park, Jae-Il, Shi, Xiaobing, Bender, Timothy P., Bushweller, John H., Park, Kwon-Sik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849394/
https://www.ncbi.nlm.nih.gov/pubmed/35171684
http://dx.doi.org/10.1126/sciadv.abl4618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849394/
https://www.ncbi.nlm.nih.gov/pubmed/35171684
http://dx.doi.org/10.1126/sciadv.abl4618

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