Evidence for accelerated aging in mammary epithelia of women carrying germline BRCA1 or BRCA2 mutations

During aging in the human mammary gland, luminal epithelial cells lose lineage fidelity by expressing markers normally expressed in myoepithelial cells. We hypothesize that loss of lineage fidelity is a general manifestation of epithelia that are susceptible to cancer initiation. In the present stud...

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Detalles Bibliográficos
Autores principales: Shalabi, Sundus F., Miyano, Masaru, Sayaman, Rosalyn W., Lopez, Jennifer C., Jokela, Tiina A., Todhunter, Michael E., Hinz, Stefan, Garbe, James C., Stampfer, Martha R., Kessenbrock, Kai, Seewaldt, Victoria E., LaBarge, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849557/
https://www.ncbi.nlm.nih.gov/pubmed/35187501
http://dx.doi.org/10.1038/s43587-021-00104-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849557/
https://www.ncbi.nlm.nih.gov/pubmed/35187501
http://dx.doi.org/10.1038/s43587-021-00104-9

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