53BP1/shieldin-dependent DSB processing in BRCA1-deficient cells requires CST/Polα/primase fill-in synthesis

PARPi efficacy in BRCA1-deficient cells depends on 53BP1 and shieldin, which have been proposed to limit single-stranded DNA at DSBs by blocking resection and/or through CST/Polα/primase-mediated fill-in. We show that—like 53BP1/shieldin and CST/Polα—primase promotes radial chromosome formation in P...

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Detalles Bibliográficos
Autores principales: Mirman, Zachary, Sasi, Nanda Kumar, King, Ashleigh, Chapman, J. Ross, de Lange, Titia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849574/
https://www.ncbi.nlm.nih.gov/pubmed/35027730
http://dx.doi.org/10.1038/s41556-021-00812-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849574/
https://www.ncbi.nlm.nih.gov/pubmed/35027730
http://dx.doi.org/10.1038/s41556-021-00812-9

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